Clone | Natalizumab | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Catalog # | SIM0018 | ||||||||||||
Category | InVivoSIM™ Biosimilar Antibodies | ||||||||||||
Price |
|
This non-therapeutic biosimilar antibody uses the same variable regions from the therapeutic antibody Natalizumab making it ideal for research use. This Natalizumab biosimilar reacts with human VLA-4 α chain also known as CD49d and integrin alpha 4. VLA-4 is a 150 kDa glycoprotein belonging to the integrin family that is expressed by many cell types including T and B lymphocytes, monocytes, eosinophils, basophils, mast cells, thymocytes, NK cells, and dendritic cells. Integrin α4 associates with integrin β7 to form integrin α4β7 also known as LPAM-1 as well as integrin β1 (CD29) to form integrin α4β1 also known as VLA-4. Integrin α4 plays roles in adhesion and T cell co-stimulation. Integrin α4 ligands include VCAM-1, MAdCAM-1, and fibronectin.
Isotype | Human IgG4, κ |
---|---|
Recommended Isotype Control(s) | InVivoMAb polyclonal human IgG |
Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
Immunogen | Human integrin α4β7 |
Reported Applications | Functional assays Flow cytometry |
Formulation | PBS, pH 7.0 Contains no stabilizers or preservatives |
Endotoxin | <1EU/mg (<0.001EU/μg) Determined by LAL gel clotting assay |
Aggregation | <5% Determined by DLS |
Purity | >95% Determined by SDS-PAGE |
Sterility | 0.2 μm filtration |
Production | Purified from tissue culture supernatant in an animal free facility |
Purification | Protein A |
Molecular Weight | 150 kDa |
Murine Pathogen Tests | Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative |
Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |