InVivoSIM anti-human IL-12 p40 (Ustekinumab Biosimilar)

Clone Ustekinumab
Catalog # SIM0020
Category InVivoSIM™ Biosimilar Antibodies
Price
Size Regular Price
1mg $ 217.00
5mg $ 843.00
25mg $ 2,942.00
50mg $ 4,229.00
100mg $ 7,526.00
About InVivoSIM anti-human IL-12 p40 (Ustekinumab Biosimilar)

This non-therapeutic biosimilar antibody uses the same variable regions from the therapeutic antibody Ustekinumab making it ideal for research use. This Ustekinumab biosimilar reacts with human p40 also known as IL-12β. p40 is a 40 kDa subunit of IL-12 and IL-23. IL-12 is a heterodimeric cytokine composed of subunits IL-12α p35 and IL-12β p40. The p40 subunit of IL-12 also combines with p19, a protein that shows no biological activity by itself, to form IL-23. IL-12 is secreted by activated monocytes, macrophages, and dendritic cells while IL-23 is secreted by activated dendritic cells and epithelial cells. IL-12 plays roles in T lymphocyte differentiation, IFNγ production, and NK cell cytotoxicity. The C17.8 antibody has been shown to neutralize both IL-12 and IL-23 bioactivity. Ustekinumab is used for the treatment of Crohn’s disease, plaque psoriasis, and psoriatic arthritis. 

InVivoSIM anti-human IL-12 p40 (Ustekinumab Biosimilar) Specifications
IsotypeHuman IgG1, κ
Recommended Isotype Control(s)InVivoPlus human IgG1 isotype control
Recommended Dilution BufferInVivoPure pH 7.0 Dilution Buffer
ImmunogenHuman IL-12 p40
Reported ApplicationsFunctional assays
FormulationPBS, pH 7.0
Contains no stabilizers or preservatives
Endotoxin<1EU/mg (<0.001EU/μg)
Determined by LAL gel clotting assay
Aggregation<5%
Determined by DLS
Purity>95%
Determined by SDS-PAGE
Sterility0.2 µm filtration
ProductionPurified from tissue culture supernatant in an animal free facility
PurificationProtein A
Molecular Weight150 kDa
Murine Pathogen TestsEctromelia/Mousepox Virus: Negative
Hantavirus: Negative
K Virus: Negative
Lactate Dehydrogenase-Elevating Virus: Negative
Lymphocytic Choriomeningitis virus: Negative
Mouse Adenovirus: Negative
Mouse Cytomegalovirus: Negative
Mouse Hepatitis Virus: Negative
Mouse Minute Virus: Negative
Mouse Norovirus: Negative
Mouse Parvovirus: Negative
Mouse Rotavirus: Negative
Mycoplasma Pulmonis: Negative
Pneumonia Virus of Mice: Negative
Polyoma Virus: Negative
Reovirus Screen: Negative
Sendai Virus: Negative
Theiler’s Murine Encephalomyelitis: Negative
StorageThe antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
Application References