Clone | Tanezumab | ||||||||||||
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Catalog # | SIM0017 | ||||||||||||
Category | InVivoSIM™ Biosimilar Antibodies | ||||||||||||
Price |
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This non-therapeutic biosimilar antibody uses the same variable regions from the therapeutic antibody Tanezumab making it ideal for research use. This Tanezumab biosimilar reacts with human nerve growth factor (NGF), a neurotrophic factor involved in the regulation of growth, maintenance, proliferation, and survival of certain neurons. NGF is essential for the development and phenotypic maintenance of neurons in the peripheral nervous system (PNS) and for the functional integrity of cholinergic neurons in the central nervous system (CNS). Tanezumab was developed against nerve growth factor as a treatment for pain via a novel mechanisms different from conventional pain-killer drugs.
Isotype | Human IgG2, κ |
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Recommended Isotype Control(s) | InVivoPlus human IgG2 isotype control |
Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
Mutations | _ |
Immunogen | Human NGF |
Reported Applications | NGF neutralization ELISA |
Formulation | PBS, pH 7.0 Contains no stabilizers or preservatives |
Endotoxin | <1EU/mg (<0.001EU/μg) Determined by LAL gel clotting assay |
Aggregation | <5% Determined by DLS |
Purity | >95% Determined by SDS-PAGE |
Sterility | 0.2 μM filtered |
Production | Purified from cell culture supernatant |
Purification | Protein A |
Molecular Weight | 150 kDa |
Murine Pathogen Tests | Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative |
Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |