InVivoSIM anti-human IL-6R (Tocilizumab Biosimilar)
| Clone | Tocilizumab | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Catalog # | SIM0014 | ||||||||||||
| Category | InVivoSIM™ Biosimilar Antibodies | ||||||||||||
| Price |
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This non-therapeutic biosimilar antibody uses the same variable regions from the therapeutic antibody Tocilizumab making it ideal for research use. This Tocilizumab biosimilar reacts with human IL-6 receptor also known as CD126. IL-6R is an 80 kDa type I cytokine receptor and a member of the immunoglobulin superfamily. IL-6R is expressed by activated T and B lymphocytes, monocytes, hepatocytes, and plasma cells. The IL-6 receptor α chain binds IL-6 but requires association with gp130 to initiate signal transduction. Upon IL-6 binding the IL-6R complex influences antigen-specific immune responses, inflammatory responses, neuronal development, and is a major mediator of the acute phase reaction. Tocilizumab binds to both soluble and membrane bound IL-6R and blocks the binding of IL-6 to IL-6R.
| Isotype | human IgG1 |
| Recommended Isotype Control(s) | InVivoPlus™ human IgG1 isotype control |
| Recommended Dilution Buffer | InVivoPure™ pH 7.0 Dilution Buffer |
| Immunogen | Human IL-6R |
| Reported Applications |
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| Formulation |
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| Endotoxin |
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| Aggregation |
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| Purity |
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| Sterility | 0.2 μM filtered |
| Production | Purified from cell culture supernatant |
| Purification | Protein A |
| Molecular Weight | 150 kDa |
| Murine Pathogen Test Results |
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| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
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