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[#BE0329]InVivoMAb anti-mouse CD71 (TfR1)

관리자 2020-03-12 Views 1,859

About InVivoMAb anti-mouse CD71 (TfR1)

The 8D3 monoclonal antibody reacts with mouse CD71 also known as transferrin receptor protein 1 (TfR1). CD71 is a 170-180 kDa type II homodimeric transmembrane glycoprotein which is expressed on the surface of proliferating cells, reticulocytes, and erythroid precursors. CD71 plays a role in the control of cellular proliferation and is required for iron import from transferrin into cells by endocytosis. CD71 is expressed on malignant cells at high levels and its expression correlates with cancer progression. This high expression on malignant cells along with CD71’s ability to internalize, and the necessity of iron for cancer cell proliferation make the transferrin receptor an attractive target to exploit for the delivery of drugs into malignant cells. The 8D3 antibody has been shown to deplete CD71+ cells in vivo.

InVivoMAb anti-mouse CD71 (TfR1) Specifications

Isotype

Rat IgG2a

Recommended Isotype Control(s)InVivoMAb rat IgG2a isotype control, anti-trinitrophenol(BE0089)
Recommended InVivoPure Dilution BufferInVivoPure pH 7.0 Dilution Buffer(IP0070)
Immunogen

Mouse transformed endothelioma cell line t.end1

Reported Applications
  • in vivo depletion of CD71+ cells
  • Immunofluorescence
  • Immunohistochemistry (frozen)
  • Western blot
Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives
Endotoxin
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay
Purity
  • >95%
  • Determined by SDS-PAGE
Sterility

0.2 μM filtered

Production

Purified from tissue culture supernatant in an animal free facility

Purification

Protein G

Molecular Weight

150 kDa

Storage

The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.


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