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[#BE0330]InVivoMAb anti-mouse CD69

관리자 2020-03-12 Views 2,855

About InVivoMAb anti-mouse CD69

The CD69.2.2 monoclonal antibody reacts with mouse CD69, an 85 kDa type II C-type lectin. CD69 expression is rapidly induced upon cell activation in all leukocytes. CD69 is thought to be a negative regulator of the immune response in part through modulating the production of TGF-β. Studies in CD69-deficient mice have revealed that CD69 plays crucial roles in the pathogenesis of various inflammatory diseases including arthritis, asthma, and colitis. When administered in vivo the CD69.2.2 antibody causes CD69 to be internalized but does not deplete CD69+ cells. Anti-CD69-treated mice resemble CD69-/- mice to a remarkable degree. The CD69.2.2 antibody has been shown to activate NK cells in vivo and in vitro and promote anti-tumor responses.

InVivoMAb anti-mouse CD69 Specifications

Isotype

Mouse IgG1, κ

Recommended Isotype Control(s)InVivoMAb mouse IgG1 isotype control, unknown specificity(BE0083)
Recommended InVivoPure Dilution BufferInVivoPure pH 7.0 Dilution Buffer(IP0070)
Immunogen

CD69+ murine 300-19 pre-B cells

Reported Applications
  • in vivo down-regulation of CD69 expression
  • Functional assays
Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives
Endotoxin
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay
Purity
  • >95%
  • Determined by SDS-PAGE
Sterility

0.2 μM filtered

Production

Purified from tissue culture supernatant in an animal free facility

Purification

Protein A

Molecular Weight

150 kDa

Storage

The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.


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